Ciprofloxacin tablets are indicated for the treatment of a wide variety of infections caused by gram-positive and gram-negative organisms including Pseudomonas. These include respiratory tract infections, urinary tract infections, skin and soft tissue infections, surgical infections, bone and joint infections, gynecological infections, gastrointestinal infections, sexually-transmitted diseases, bacteremia, septicemia, and infections in immunocompromised patients.
Hypersensitivity of Ciprofloxacin and other quinolone derivatives. Pregnancy and lactation. Children below the age of 12 years.
To be used with caution in patients with CNS disorders. Dosage to be reduced in patients with impaired kidney function. Concurrent administration of antacids to be avoided. Patients receiving Ciprofloxacin should be well hydrated to prevent crystalluria.
Ciprofloxacin is generally well-tolerated. The commonly reported side effects are diarrhea, vomiting, abdominal pain, headache, restlessness and rash. Other side effects reported very rarely are arthralgia, and increase in serum transaminase level.
Ciprofloxacin absorption when co-administered with magnesium-aluminum antacids. Other cations, such as calcium and probably zinc appear to interact in similar manner. Theophylline serum concentration have been found to be markedly elevated when co-administered with Ciprofloxacin. At doses used for systematic infections, Ciprofloxacin decreases theopylline clearance by approximately 30%. A decreased Ciprofloxacin absorption.
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