Cefuclav | Iberica Verheilen Pharmaceuticals

OUR PRODUCTS

ANTIBIOTICS

GASTRO-INTESTINAL PRODUCTS

ANTI-HISTAMINE

ANTI-HYPERTENSIVE

ANTI-EPILEPTIC/NEUROPATHIC PAIN

MULTIVITAMINS

FORMULATION

Each film coated tablet contains:
Cefuroxime Axetil USP eq. to anhydrous Cefuroxime 500mg
Clavulanate Potassium USP eq. to Clavulanic Acid 125mg

INDICATION

For treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsilitis, pharyngitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

DOSAGE AND ADMINISTRATION

Uncomplicated Urinary tract Infection: Adult: 125mg twice daily
Respiratory Tract Infections
Adult:250 – 500mg twice daily Child:>3 month:125 mg twice daily or 10 mg/kg twice daily. Max Dose: 250mg daily.
Uncomplicated Gonorrhea
Adult: 1g as a single dose. 1g oral probenecid may be given concurrently.
Otitis Media
Child:≥ 2yr. 250 mg twice daily or 15 mg/kg twice daily up to 500 mg daily
Meningitis Adult: 3g every 8 hrs
Child:200-240 mg/kg/day in 3-4 divided doses,decreased to 100 mg/kg/day after 3 days or once symptoms have improved.
Neonate
100mg/kg/day ,decreased to 50mg/kg/day when control has been achieved.
Renal Impairment
Patients undergoing haemodialysis should receive an additional 750mg dose after each dialysis.;those undergoing continous peritoneal dialysis may be given 750mg twice daily.

CrCl(mL/min)	Dosage Recommendation
10-20	750mg twice daily
<10	750mg twice daily

OVERDOSAGE

Reports indicate that the ingestion of large amounts of Clarithromycin can be expected to produce gastro-instestinal symptoms. Adverse reactions accompanying overdosage should be treated by gastric lavage and general supportive measures. One patient who had a history of bipolar disorders ingested 8 grams of Clarithromycin and showed altered mental status, paranoid behavior, hypokalaemia. As with other macrolides, Clarithromycin serum levels are not expected to be appropriately affected by hemodialysis or peritoneal dialysis.

CONTRAINDICATION

Clarithromycin is contraindicated in patients with known hypersensitivity to clarithromycin, erythromycin or any of the macrolide antibiotics. Clarithromycin is contraindicated in patients receiving terfenadine therapy who have pre-existing cardiac abnormalities (arrhythmia, bradycardia, QT interval prolongation, ischemic heart disease, congestive heart failure) or electrolyte disturbances.

PRECAUTIONS

Caution is required in patients with impaired renal or hepatic function. It should not be used during pregnancy if possible: high doses have been associated with embryotoxicity in animal studies.

ADVERSE EFFECTS

Ciprofloxacin is generally well-tolerated. The commonly reported side effects are diarrhea, vomiting, abdominal pain, headache, restlessness and rash. Other side effects reported very rarely are arthralgia, and increase in serum transaminase level.

DRUG INTERACTIONS

Ciprofloxacin absorption when co-administered with magnesium-aluminum antacids. Other cations, such as calcium and probably zinc appear to interact in similar manner. Theophylline serum concentration have been found to be markedly elevated when co-administered with Ciprofloxacin. At doses used for systematic infections, Ciprofloxacin decreases theopylline clearance by approximately 30%. A decreased Ciprofloxacin absorption.