Congestive Heart failure: In general, calcium channel blockers should be used with caution in patients with heart failure. Electrolyte Imbalance: Electrolyte imbalances are common in patients with renal impairment, with or without diabetes, and should be addressed. Lithium: Losartan reduce lithium excretions; hence, serum lithium, and should be monitored carefully if lithium salts are to be co-administered with LOSARTAN potassium + AMLODIPINE besilate tablets. Hypotension: Excessive fall of blood pressure can occur with amlodipine in some patient, especially the elderly. In patients who are intravascularly volume-depleted, symptomatic. Pregnancy: Drugs the act as directly on the RAAS can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, LOSARTAN potassium + AMLODIPINE besilate should be discontinued as soon as possible. Oligohydramnios has also been reported, presumable resulting from decreased fatal renal function. Lactation: It is not known whether losartan or amlodipine is excreted in human milk. In the absence of this information, it is recommended that nursing may be discontinued while the combination is administered. Renal Impairment: The combination should be used with caution in patients with