Hypersensitivity to Ciprofloxacin and other quinolone derivative. Pregnancy and lactation. Children below 12 years of age.
To be used with caution in patients with CNS disorders. Dosage to be reduced in patients with impaired kidney function. Concurrent administration of antacids to be avoided. Patients receiving Ciprofloxacin should be well-hydrated to prevent crystalluria.
Ciprofloxacin is generally well tolerated. The commonly reported side effects are diarrhea, vomiting, abdominal pain, headache, restlessness and rash. Other side effects reported very rarely are arthralgia and increase in serum transaminase level.
Ciprofloxacin absorption is decreased when co-administered with magnesium-aluminum antacids. Other actions, such as calcium, iron and probably zinc appear to interact in a similar manner. Theophylline serum concentrations have been found to be markedly elevated when co-administered with Ciprofloxacin. At doses used for systemic infections, Ciprofloxacin decreases theophylline clearance by approximately 30%. A decreased Ciprofloxacin absorption have been observed with concurrent Sucralfate administration. It is possible that Rifampicin may induce the metabolism of Ciprofloxacin leading to lower serum concentration and failure therapy. The combination of Ciprofloxacin and Chloramphenicol may be antagonistic.
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